Mastelli Polynucleotides

Plinest® is the flagship aesthetic medicine line by Mastelli, a family-owned Italian biopharmaceutical company with more than 70 years of expertise in regenerative medicine. Rooted in Sanremo since 1952 and backed by over 100 scientific publications, Mastelli has pioneered the use of Polynucleotides High Purification Technology (PN HPT™) – a powerful, natural-origin DNA extract derived from freshwater salmon trout.

This unique technology enhances fibroblast activity, promotes tissue repair, and regenerates the skin from within. Plinest® is a medical device based on PN HPT™, created to improve skin quality, elasticity, and radiance through an evidence-based and holistic approach.

Building on the success of PN HPT™ technology, Newest® represents a new frontier in aesthetic medicine. This medical device is the result of an advanced synergy between Polynucleotides High Purification Technology (PN HPT™), Hyaluronic Acid, and Mannitol — offering enhanced skin bio-regeneration, deep hydration, and antioxidant protection.

Born from Mastelli’s decades-long legacy in regenerative science, Newest® was developed to target skin aging and loss of elasticity across wider treatment areas and more demanding skin conditions. It is especially effective in restoring turgor, elasticity, and hydration in both younger and mature skin.